• PDB 8CCC | dpdb_g2ic6803The Fk1 domain of FKBP51 in complex with 2-(3-((R)-1-(((S)-1-((S)-2-(5-chlorothiophen-2-yl)propanoyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acidUpdated Oct 5, 2026
• PDB 3O5F | dpdb_v3xtxcz7Fk1 domain of FKBP51, crystal form VIIUpdated Oct 5, 2026
• PDB 8CHR | dpdb_nqsp0qllThe FK1 domain of FKBP51 in complex with (1S,5S,6R)-10-((R)-(3,5-dichlorophenyl)sulfonimidoyl)-3-(pyridin-2-ylmethyl)-5-vinyl-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Oct 5, 2026
• PDB 4W9P | dpdb_pe3skvb2The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Oct 4, 2026
• PDB 3O5L | dpdb_woirptv3Fk1 domain mutant A19T of FKBP51, crystal form IUpdated Oct 4, 2026
• PDB 8CCA | dpdb_j1fsuxp7The Fk1 domain of FKBP51 in complex with SAFit1Updated Oct 4, 2026
• PDB 3O5Q | dpdb_xtbejjd5Fk1 domain mutant A19T of FKBP51, crystal form IV, in presence of DMSOUpdated Oct 3, 2026
• PDB 5DIV | dpdb_nk9w6uuvThe Fk1 domain of FKBP51 in complex with the new synthetic ligand (S)-N-(1-carbamoylcyclopentyl)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxamideUpdated Oct 3, 2026
• PDB 7R0L | dpdb_x84xczd1Structure of the FK1 domain of the FKBP51 G64S variant in complex with SAFit1Updated Oct 3, 2026
• PDB 8CCE | dpdb_v72b7j33The Fk1 domain of FKBP51 in complex with 2-(3-((R)-1-(((S)-1-((S)-2-(5-chlorothiophen-2-yl)butanoyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acidUpdated Oct 2, 2026
• PDB 4DRQ | dpdb_4ubujmdlExploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-1-((S)-1-(3,5-dichlorophenylsulfonyl)piperidine-2-carbonyloxy)-3-(3,4-dimethoxy -phenyl)propyl)phenoxy)acetic acidUpdated Oct 2, 2026
• PDB 5DIU | dpdb_49tmszspThe Fk1 domain of FKBP51 in complex with the new synthetic ligand 2-(3-((R)-1-((S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxamido)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acidUpdated Oct 2, 2026
• PDB 6TX4 | dpdb_sv9fqh6hCRYSTAL STRUCTURE OF HUMAN FKBP51 FK1 DOMAIN A19T MUTANT IN COMPLEX WITH 2-PYRIDONEUpdated Oct 2, 2026
• PDB 4DRI | dpdb_gzvzj3v9Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTORUpdated Oct 2, 2026
• PDB 4JFI | dpdb_gf0t1dmtIncreasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dioneUpdated Oct 2, 2026
• PDB 8CHP | dpdb_61imiiw4The FK1 domain of FKBP51 in complex with (1S,5S,6R)-10-((S)-(3,5-dichlorophenyl)sulfinyl)-3-(pyridin-2-ylmethyl)-5-vinyl-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Oct 2, 2026
• PDB 8CHQ | dpdb_9ws04m2wThe FK1 domain of FKBP51 in complex with (1S,5S,6R)-10-((S)-3,5-dichloro-N-methylphenylsulfonimidoyl)-3-(pyridin-2-ylmethyl)-5-vinyl-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Oct 1, 2026
• PDB 4JFM | dpdb_qfmzvcskIncreasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 2-(3,4-dimethoxyphenoxy)ethyl (2S)-1-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carboxylateUpdated Oct 1, 2026
• PDB 3O5J | dpdb_8jcnslanFk1 domain of FKBP51, crystal form IIIUpdated Oct 1, 2026
• PDB 8BA6 | dpdb_ffgvjke6Structure of the FK1 domain of the FKBP51 G64S variant in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-15,15,16-trimethyl-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0^5,^10]tetracosa-1(24),20,22-triene-4,11,14,17-tetroneUpdated Oct 1, 2026
• PDB 4TW6 | dpdb_q031rwatThe Fk1 domain of FKBP51 in complex with iFit1Updated Oct 1, 2026
• PDB 8BAJ | dpdb_nsegpfkrStructure of the FK1 domain of the FKBP51 G64S variant in complex with (1S,5S,6R)-10-((3,5-dichlorophenyl)sulfonyl)-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Oct 1, 2026
• PDB 7ETV | dpdb_2ardi4quThe FK1 domain of FKBP51 in complex with peptide-inhibitor hit DFPFVUpdated Oct 1, 2026
• PDB 3O5E | dpdb_fhz7rbt8Fk1 domain of FKBP51, crystal form VIUpdated Sep 30, 2026
• PDB 7ETU | dpdb_zmu54uhkThe FK1 domain of FKBP51 in complex with peptide-inhibitor hit SFPFTUpdated Sep 30, 2026
• PDB 7AWF | dpdb_4pm8rymfThe Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-15,15,16-trimethyl-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0^5,^10]tetracosa-1(24),20,22-triene-4,11,14,17-tetroneUpdated Sep 30, 2026
• PDB 7AOT | dpdb_fw9w8zbvThe Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetroneUpdated Sep 30, 2026
• PDB 8CCH | dpdb_w1q8spduThe Fk1 domain of FKBP51 in complex with 2-(3-((1R)-1-(((2S)-1-(2-cyclohexyl-2-(thiophen-2-yl)acetyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acidUpdated Sep 30, 2026
• PDB 6TX5 | dpdb_wztqfqxiCRYSTAL STRUCTURE OF HUMAN FKBP51 FK1 DOMAIN A19T MUTANT IN COMPLEX WITH 4-METHYLIMIDAZOLEUpdated Sep 30, 2026
• PDB 4DRK | dpdb_s4hl88obEVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acidUpdated Sep 30, 2026
• PDB 5BXJ | dpdb_r2sd2vouComplex of the Fk1 domain mutant A19T of FKBP51 with 4-NitrophenolUpdated Sep 30, 2026
• PDB 6TX6 | dpdb_3jmsl8ckCRYSTAL STRUCTURE OF HUMAN FKBP51 FK1 DOMAIN A19T MUTANT IN COMPLEX WITH NICOTINAMIDEUpdated Sep 30, 2026
• PDB 7APS | dpdb_1ad5dlvqThe Fk1 domain of FKBP51 in complex with (2S)-2-((1S,5R,6R)-10-((3,5-dichlorophenyl)sulfonyl)-2-oxo-5-vinyl-3,10-diazabicyclo[4.3.1]decan-3-yl)propanoic acidUpdated Sep 30, 2026
• PDB 8R5K | dpdb_79rsvc9uThe Fk1 domain of FKBP51 in complex with Antascomicine BUpdated Sep 30, 2026
• PDB 8CCB | dpdb_eg5i38keThe Fk1 domain of FKBP51 in complex with 2-(3-((1R)-1-(((2S)-1-(2-(5-chlorothiophen-2-yl)-2-cyclohexylacetyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acidUpdated Sep 29, 2026
• PDB 4TW7 | dpdb_c2imi7t4The Fk1 domain of FKBP51 in complex with iFit4Updated Sep 29, 2026
• PDB 3O5O | dpdb_jj2vpjqfFk1 domain mutant A19T of FKBP51, crystal form IIIUpdated Sep 29, 2026
• PDB 4TX0 | dpdb_079jlr08The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Sep 29, 2026
• PDB 3O5R | dpdb_ak5lfjqyComplex of Fk506 with the Fk1 domain mutant A19T of FKBP51Updated Sep 28, 2026
• PDB 6TX7 | dpdb_xzfft6s3CRYSTAL STRUCTURE OF HUMAN FKBP51 FK1 DOMAIN A19T MUTANT IN COMPLEX WITH 2-PIPERIDONEUpdated Sep 28, 2026
• PDB 3O5M | dpdb_0ui2gxvjFk1 domain mutant A19T of FKBP51, crystal form IIUpdated Sep 28, 2026
• PDB 4JFK | dpdb_qtl68nu6Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with (1S,6R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-10-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Sep 28, 2026
• PDB 4JFL | dpdb_3vzugzu2Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-oneUpdated Sep 28, 2026
• PDB 4DRO | dpdb_bcdvd3kqEVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH (1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl (2S)-1-{[(1R,2S)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidine-2-carboxylateUpdated Sep 27, 2026
• PDB 4W9Q | dpdb_7hlw85w9The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Sep 27, 2026
• PDB 5OBK | dpdb_xc6ilsmwThe Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-((3,5-dichlorophenyl)sulfonyl)-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-oneUpdated Sep 27, 2026
• PDB 8CCG | dpdb_gw33ot0fThe Fk1 domain of FKBP51 in complex with (2R,5S,12S)-12-(thiophen-2-yl)-2-[2-(3,4-dimethoxyphenyl)ethyl]-15,15-dimethyl-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0^5,^10]tetracosa-1(24),20,22-triene-4,11,14,17-tetroneUpdated Sep 27, 2026
• PDB 4R0X | dpdb_iz37erp1Allosteric coupling of conformational transitions in the FK1 domain of FKBP51 near the site of steroid receptor interactionUpdated Sep 27, 2026
• PDB 7AOU | dpdb_f0a3xbheThe Fk1 domain of FKBP51 in complex with (2'R,5'S,12'R)-12'-cyclohexyl-2'-[2-(3,4-dimethoxyphenyl)ethyl]-3',19'-dioxa-10',13',16'-triazaspiro[cyclopropane-1,15'- tricyclo[18.3.1.0-5,10]tetracosane]-1'(24'),20',22'-triene-4',11',14',17'-tetroneUpdated Sep 27, 2026
• PDB 4DRM | dpdb_9lsp1u45EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acidUpdated Sep 27, 2026