Ensemble refinement model

PDB 5WAL|dpdb_37ocqj7x

Ensemble refinement model

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Program
PHENIX phenix.ensemble_refinement
Model type
Ensemble
Purpose
Refinement
Atoms
96,664
Residues
286
Protein chains
1
Alternate-location fraction
0%
Ligand
9ZS

Evaluations

R-work
0.174
R-free
0.249
Clashscore
—

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Non-receptor tyrosine-protein kinase TYK2302
  • MutationsC936A Q969A E971A K972A S1016A C1142A D1023N

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations