Rerefined model

PDB 3R92|dpdb_38k0d3vt

Rerefined model

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.

Program
PHENIX 2.0_5824
Model type
Multiconformer
Purpose
Refinement
Atoms
2,006
Residues
208
Protein chains
1
Alternate-location fraction
1.92%
Ligand
06J

Evaluations

R-work
0.173
R-free
0.198
Clashscore
1.8

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Heat shock protein HSP 90-alpha226
  • ConstructN-terminal domain, UNP RESIDUES 10-236

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations