Deposited model

PDB 3R91|dpdb_3g2ku59j

Deposited model

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.

Program
PHENIX (phenix.refine)
Model type
Deposited
Purpose
Reference
Authors
Zapf, C.W., Bloom, J.D., McBean, J.L., Dushin, R.G., Nittoli, T., Otteng, M., Ingalls, C., Golas, J.M., Liu, H., Lucas, J., Boschelli, F., Vogan, E., Hu, Y., Levin, J.I.
Atoms
1,968
Residues
207
Protein chains
1
Unmodeled fraction
8.41%

Evaluations

R-work
0.186
R-free
0.199
Clashscore
3.6

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Heat shock protein HSP 90-alpha226
  • ConstructN-terminal domain, UNP RESIDUES 10-236
  • MutationsDelta 16

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations