Deposited model

PDB 7B49|dpdb_6awcijae

Deposited model

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ

Program
PHENIX 1.18.2-3874
Model type
Deposited
Purpose
Reference
Authors
Rozenberg, H., Degtjarik, O., Shakked, Z.
Atoms
4,437
Residues
410
Protein chains
3
Unmodeled fraction
2.61%
Ligands
QN8, QNN, ZN

Evaluations

R-work
0.184
R-free
0.229
Clashscore
6.5

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Cellular tumor antigen p53200
  • Constructp53 human DNA binding domain
  • MutationR273H
Entity 2
MoleculeChainsLengthOrganismUniProtDetails
DNA target21—
  • Constructp53 DNA target
  • Mutations'

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations