Deposited model

PDB 8A2B|dpdb_8xg156kc

Deposited model

EGFR kinase domain (L858R/V948R) in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide

Program
REFMAC 5.8.0253
Model type
Deposited
Purpose
Reference
Authors
Kuglstatter, A., Ehler, A.
Atoms
2,428
Residues
272
Protein chains
1
Unmodeled fraction
16.56%

Evaluations

R-work
0.210
R-free
0.258
Clashscore
9.0

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Epidermal growth factor receptor326
  • MutationsL858R V948R

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations