Ensemble refinement model

PDB 7B4E|dpdb_av5t69ep

Ensemble refinement model

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ

Program
PHENIX 2.0_5824
Model type
Ensemble
Purpose
Refinement
Atoms
76,821
Residues
201
Protein chains
2
Alternate-location fraction
0%
Ligands
EDO, PG4, QN8, QNN, ZN

Evaluations

R-work
0.169
R-free
0.213
Clashscore
—

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Cellular tumor antigen p53200
  • Constructp53 human DNA binding domain
  • MutationR282W
Entity 2
MoleculeChainsLengthOrganismUniProtDetails
DNA target11—
  • Constructp53 DNA target
  • Mutations'

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations