qFit model

PDB 7B4D|dpdb_mjjofmae

qFit model

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ

Program
Phenix 2.0_5824
Model type
Multiconformer
Purpose
Model Building
Atoms
3,165
Residues
209
Protein chains
2
Alternate-location fraction
69.86%
Ligands
FMT, QN8, QNN, ZN

Evaluations

R-work
0.190
R-free
0.243
Clashscore
—

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Cellular tumor antigen p53200
  • Constructp53 human DNA binding domain
  • MutationsR273C S240R
Entity 2
MoleculeChainsLengthOrganismUniProtDetails
DNA target12—
  • Constructp53 DNA target
  • Mutations'

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations