Deposited model
PDB 4AN3|dpdb_nadlxdkn
Deposited model
Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.
- Program
- REFMAC 5.2.0005
- Model type
- Deposited
- Purpose
- Reference
- Authors
- Rice, K.D., Aay, N., Anand, N.K., Blazey, C.M., Bowles, O.J., Bussenius, J., Costanzo, S., Curtis, J.K., Defina, S.C., Dubenko, L., Engst, S., Joshi, A.A., Kennedy, A.R., Kim, A.I., Koltun, E.S., Lougheed, J.C., Manalo, J.C.L., Martini, J.F., Nuss, J.M., Peto, C.J., Tsang, T.H., Yu, P., Johnston, S.
- Atoms
- 2,337
- Residues
- 280
- Protein chains
- 1
- Unmodeled fraction
- 6.98%
- Ligands
- ATP, MG
Evaluations
R-work
0.226
R-free
0.283
Clashscore
11.7
Macromolecules
The same in every model of this entry.
Data
L0 Raw
L1 Processed
L2 Models
L3 Evaluations