Deposited model

PDB 5AMN|dpdb_ub8ukefs

Deposited model

The Discovery of 2-Substituted Phenol Quinazolines as Potent and Selective RET Kinase Inhibitors

Program
PHENIX (PHENIX.REFINE)
Model type
Deposited
Purpose
Reference
Authors
Newton, R., Bowler, K., Burns, E.M., Chapman, P., Fairweather, E., Fritzl, S., Goldberg, K., Hamilton, N.M., Holt, S.V., Hopkins, G.V., Jones, S.D., Jordan, A.M., Lyons, A., McDonald, N.Q., Maguire, L.A., Mould, D.P., Purkiss, A.G., Small, H.F., Stowell, A., Thomson, G.J., Waddell, I.D., Waszkowycz, B., Watson, A.J., Ogilvie, D.J.
Atoms
2,310
Residues
289
Protein chains
1
Unmodeled fraction
3.34%

Evaluations

R-work
0.183
R-free
0.237
Clashscore
8.8

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET299
  • ConstructKINASE DOMAIN, RESIDUES 705-826,841-1012

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations