Deposited model

PDB 3R92|dpdb_38k0d3vt

Deposited model

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.

Program
PHENIX (phenix.refine)
Model type
Deposited
Purpose
Reference
Authors
Zapf, C.W., Bloom, J.D., McBean, J.L., Dushin, R.G., Golas, J.M., Liu, H., Lucas, J., Boschelli, F., Vogan, E.M., Levin, J.I.
Atoms
2,029
Residues
208
Protein chains
1
Unmodeled fraction
7.96%

Evaluations

R-work
0.176
R-free
0.194
Clashscore
4.7

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Heat shock protein HSP 90-alpha226
  • ConstructN-terminal domain, UNP RESIDUES 10-236

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations