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Deposited model

PDB 4I22|dpdb_7ok0exnq

Deposited model

Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

Program
CNX
Model type
Deposited
Purpose
Reference
Authors
Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.
Atoms
2,575
Residues
297
Protein chains
1
Unmodeled fraction
9.73%

Evaluations

R-work
0.197
R-free
0.224
Clashscore
8.6

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Epidermal growth factor receptor329
  • ConstructUNP residues 695-1022, EGFR kinase domain
  • MutationsT790M L858R V948R

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations