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PDB 4I22|dpdb_7ok0exnq

qFit model

Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

Program
Phenix 2.0_5824
Model type
Multiconformer
Purpose
Model Building
Atoms
4,673
Residues
297
Protein chains
1
Alternate-location fraction
83.5%
Ligands
IRE, SO4

Evaluations

R-work
0.161
R-free
0.190
Clashscore
—

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Epidermal growth factor receptor329
  • ConstructUNP residues 695-1022, EGFR kinase domain
  • MutationsT790M L858R V948R

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations