Deposited model

PDB 7B4E|dpdb_av5t69ep

Deposited model

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ

Program
PHENIX 1.18.2-3874
Model type
Single Conformer
Purpose
Model Building
Authors
Degtjarik, O., Rozenberg, H., Shakked, Z.
Atoms
2,323
Residues
201
Protein chains
2
Unmodeled fraction
4.74%
Ligands
QN8, QNN, ZN

Evaluations

R-work
0.166
R-free
0.201
Clashscore
5.9

Macromolecules

The same in every model of this entry.

Entity 1
MoleculeChainsLengthOrganismUniProtDetails
Cellular tumor antigen p53200
  • Constructp53 human DNA binding domain
  • MutationR282W
Entity 2
MoleculeChainsLengthOrganismUniProtDetails
DNA target11—
  • Constructp53 DNA target
  • Mutations'

Data

L0 Raw
L1 Processed
L2 Models
L3 Evaluations