Deposited model

PDB 4ZYI|dpdb_inmo5y8i

Deposited model

Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with cpd2

Program: REFMAC 5.5.0063
Model type: Deposited
Purpose: Reference
Authors: Kallen, J.

Atoms: 846
Residues: 90
Protein chains: 1
Unmodeled fraction: 6.25%

Evaluations

R-work

0.239

R-free

0.247

Clashscore

4.4

Macromolecules

The same in every model of this entry.

Entity 1
Molecule	Chains	Length	Organism	UniProt	Details
E3 ubiquitin-protein ligase Mdm2		96	Homo sapiens9606	Q00987SIFTS · 2026_03	ConstructN-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP residues 17-111

Data

L0 Raw

L1 Processed

L2 Models

L3 Evaluations