Ensemble refinement model

PDB 4ZYC|dpdb_nrh6z1mx

Ensemble refinement model

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5

Program: PHENIX phenix.ensemble_refinement
Model type: Ensemble
Purpose: Refinement
Atoms: 155,191

Residues: 255
Protein chains: 3
Alternate-location fraction: 0%
Ligands: 4SS, SO4

Evaluations

R-work

0.160

R-free

0.210

Clashscore

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Macromolecules

The same in every model of this entry.

Entity 1
Molecule	Chains	Length	Organism	UniProt	Details
E3 ubiquitin-protein ligase Mdm2		96	Homo sapiens9606	Q00987SIFTS · 2026_03	ConstructN-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP residues 17-111 MutationL33E

Data

L0 Raw

L1 Processed

L2 Models

L3 Evaluations