Deposited model

PDB 4ZYC|dpdb_nrh6z1mx

Deposited model

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5

Program: REFMAC 5.5.0063
Model type: Deposited
Purpose: Reference
Authors: Kallen, J.

Atoms: 2,338
Residues: 255
Protein chains: 3
Unmodeled fraction: 11.46%

Evaluations

R-work

0.220

R-free

0.259

Clashscore

4.9

Macromolecules

The same in every model of this entry.

Entity 1
Molecule	Chains	Length	Organism	UniProt	Details
E3 ubiquitin-protein ligase Mdm2		96	Homo sapiens9606	Q00987SIFTS · 2026_03	ConstructN-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP residues 17-111 MutationL33E

Data

L0 Raw

L1 Processed

L2 Models

L3 Evaluations